Hydrochloride methanol → HCID 11848560, compound

HRID 1191286Notes

Reaction equation

HRID 1191286 reaction equation
[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][CH2:19][CH2:18][N:17]([CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]4)[CH:16]3[CH2:27][CH2:28][NH:29]C(=O)OC(C)(C)C)[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.CO>>[NH2:29][CH2:28][CH2:27][CH:16]1[CH:15]([NH:14][C:10]2[N:9]=[C:8]([N:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:13]=[CH:12][N:11]=2)[CH2:20][CH2:19][CH2:18][N:17]1[CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86634385HCID 86634385, compound

Product 1

HCID 11848560HCID 11848560, compoundYield 87%

Procedure

The compound 21 (102 mg) and 10% hydrogen chloride-methanol solution (2 mL) were stirred at room temperature for 5 hours. The reaction solution was concentrated, added aqueous 2N sodium hydroxide solution and then extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, concentrated and obtained the title compound (71 mg) having the following physical properties.

Workup

  1. concentrationThe reaction solution was concentrated
  2. additionadded aqueous 2N sodium hydroxide solution
  3. extractionextracted with dichloromethane
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-00760a7f43d4492cb17b3602af8eb3de
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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