Hydrogen chloride-ethyl acetate → HCID 68918487, compound

HRID 1191288Notes

Reaction equation

HRID 1191288 reaction equation
[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][CH2:19][CH2:18][N:17]([CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]4)[CH:16]3[CH2:27][CH2:28][NH:29][C:30]([CH:32]3[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]3)=[O:31])[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:51]>C(OCC)(=O)C>[ClH:51].[ClH:51].[ClH:51].[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][CH2:19][CH2:18][N:17]([CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]4)[CH:16]3[CH2:27][CH2:28][NH:29][C:30]([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[O:31])[N:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68917833HCID 68917833, compound

Product 1

HCID 68918487HCID 68918487, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound 23 (74 mg), ethyl acetate (0.6 mL) and 4N hydrogen chloride-ethyl acetate solution (0.6 mL) were stirred at room temperature for 2 hours. The reaction solution was concentrated and obtained the title compound (80 mg) having the following physical properties.

Workup

  1. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-49dc6cda0d874b78823c0d4780edcb52
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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