1,4-Dioxaspiro[4.5]decan-8-one → HCID 86634389, compound

HRID 1191297Notes

Reaction equation

HRID 1191297 reaction equation
[N:1]1([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH:15][C@H:16]3[CH2:20][CH2:19][NH:18][C@@H:17]3[CH2:21][CH2:22][CH2:23][N:24]=[N+:25]=[N-:26])[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:27]1[C:31]2([CH2:36][CH2:35][C:34](=O)[CH2:33][CH2:32]2)[O:30][CH2:29][CH2:28]1>>[N:1]1([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH:15][C@H:16]3[CH2:20][CH2:19][N:18]([CH:34]4[CH2:35][CH2:36][C:31]5([O:30][CH2:29][CH2:28][O:27]5)[CH2:32][CH2:33]4)[C@@H:17]3[CH2:21][CH2:22][CH2:23][N:24]=[N+:25]=[N-:26])[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 86634390HCID 86634390, compound

Product 1

HCID 86634389HCID 86634389, compound

Procedure

The same procedure as a series of reactions of Example 9 was carried out, except that 4-azepan-1-yl-N-[(2R,3S)-2-(3-azidopropyl)pyrrolidin-3-yl]-6-chloropyrimidin-2-amine was used in place of the compound 8 and 1,4-dioxaspiro[4.5]decan-8-one was used in place of cyclohexanone in the process of Example 9, to obtain the title compound (1.25 g) having the following physical properties.

Sources & evidence

ORD record
ord-c8516f259e274677a02c05f99adef813
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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