Hydrochloric Acid → HCID 86697003, compound

HRID 1191316Notes

Reaction equation

HRID 1191316 reaction equation
[Br:1][C:2]1[C:3]([O:18][CH3:19])=[N:4][N:5]([CH3:17])[C:6]=1[CH2:7][N:8](C)[C:9](=O)OC(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[Br:1][C:2]1[C:3]([O:18][CH3:19])=[N:4][N:5]([CH3:17])[C:6]=1[CH2:7][NH:8][CH3:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86697004HCID 86697004, compound

Product 1

HCID 86697003HCID 86697003, compoundYield 120.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of compound 91 (1613 mg, 4.826 mmol) in DCM (10 ml) was added 4N HCl in dioxane. (10 ml). The solution was allowed to stir at room temperature for 2 hours, then the reaction mixture was concentrated to give compound 196 (1357 mg, 104%) as a yellow solid.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d32522f9369544d0998b2e1727b1c507
Source dataset
uspto-grants-2014_03
Patent number
US08680111B2

Reaction notes

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