反应详情

温度

60 °C

A 7 mL vial was charged with the crude 4-(3-iodo-2-methylpropyl)-6-methyl-4H-benzo[1,4]oxazin-3-one (1 equiv), Et3N (0.5 mL) and the secondary amine (1.2-1.5 equiv). This mixture was shaken at 60° C. for 72 h and thereafter diluted with MeOH (10 mL) and concentrated with basic Al2O3 (2 g) and purified by flash chromatography.

1. concentrationconcentrated with basic Al2O3 (2 g)
2. custompurified by flash chromatography