反应详情

温度

60 °C

To a solution of methyl 3-(5-methoxy-2-phenylindol-1-ylmethyl)benzoate (48.6 mg) in tetrahydrofuran-methanol (7/3, 1.1 mL) was added 2 mol/L aqueous sodium hydroxide solution (0.196 mL) at room temperature, and the mixture was stirred at 60° C. for 2 hours. 1 mol/L Hydrochloric acid (10 mL) was added to the reaction mixture at room temperature and this resulting mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the title compound (44.7 mg).

1. extractionthis resulting mixture was extracted with ethyl acetate
2. washThe organic layer was washed successively with water and saturated saline
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure