HCID 59212645, compound → HCID 59212647, compound

HRID 1191917Notes

Reaction equation

HRID 1191917 reaction equation
[CH3:1][C:2]1([N:15]2[CH2:20][CH2:19][N:18]([CH:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([F:33])([F:32])[F:31])[CH:28]=4)[CH2:23][CH2:22]3)[C@@H:17]([CH3:34])[CH2:16]2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[CH3:34][C@H:17]1[CH2:16][N:15]([C:2]2([CH3:1])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]2)[CH2:20][CH2:19][N:18]1[CH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([C:30]([F:33])([F:31])[F:32])[CH:28]=2)[CH2:23][CH2:22]1

Participants

4

Reactant 1

HCID 59212645HCID 59212645, compound

Product 1

HCID 59212647HCID 59212647, compoundYield 152.9%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-methyl-4-{(3S)-3-methyl-4-[6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl}piperidine-1-carboxylate (0.32 g, 0.6 mmol) was dissolved in a 4 M solution of HCl in dioxane (8.0 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated to give the title compound (0.35 g) as a trihydrochloride salt. MS calculated for C21H30F3N3: (M+H)+ 382. found 382.2.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-cd1d173b17e04ec088732c9c652ed78d
Source dataset
uspto-grants-2014_03
Patent number
US08680104B2

Reaction notes

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