HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 6-(trifluoromethyl)-1H-indene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol | HCID 24820473 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-(trifluoromethyl)-1H-indene | HCID 19095510 | 96.2% |
Reaction Steps
A mixture of 5-(trifluoromethyl)indan-1-ol (1.6 g, 7.9 mmol) and p-toluenesulfonic acid (0.02 g, 0.1 mmol) in toluene (20 mL) was refluxed through a Dean-Stark trap for about 3 h. The solution was concentrated in vacuo and the residue was purified by flash chromatography on silica eluting with 5% EtOAc/hexane to afford the desired product as an oil (1.4 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680104B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-ae365f8a2466409d885ba81b20b2b61e |
| Source note | uspto-grants-2014_03 |