反应详情

A mixture of 5-(trifluoromethyl)indan-1-ol (1.6 g, 7.9 mmol) and p-toluenesulfonic acid (0.02 g, 0.1 mmol) in toluene (20 mL) was refluxed through a Dean-Stark trap for about 3 h. The solution was concentrated in vacuo and the residue was purified by flash chromatography on silica eluting with 5% EtOAc/hexane to afford the desired product as an oil (1.4 g, 96%).

1. temperaturewas refluxed through a Dean-Stark trap for about 3 h
2. concentrationThe solution was concentrated in vacuo
3. customthe residue was purified by flash chromatography on silica eluting with 5% EtOAc/hexane