反应详情

In an alternative procedure, FTY720 free base (2.27 mmol) was dissolved in ethyl acetate (16 ml) at 88 to 90° C. Then a solution of malonic acid (1.14 mmol) in ethyl acetate (3 ml) was added at 75° C., whereupon the product started to crystallize out immediately after addition. The resulting suspension was cooled to room temperature. The product was collected by filtration and was washed with ethyl acetate (2 ml). After drying at 50° C. the product (788 mg) was obtained as white crystals.

1. customto crystallize out immediately
2. additionafter addition
3. filtrationThe product was collected by filtration
4. washwas washed with ethyl acetate (2 ml)
5. dry with materialAfter drying at 50° C. the product (788 mg)
6. customwas obtained as white crystals