1-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-one → HCID 46932054, compound

HRID 1192039Notes

Reaction equation

HRID 1192039 reaction equation
Cl[C:2]1[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[C:15]1[SH:19]>>[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[C:15]1[S:19][C:2]1[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11]

Participants

3

Reactant 2

HCID 5211051-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-oneHCID 178480602HCID 178480602, compound

Product 1

HCID 46932054HCID 46932054, compound

Procedure

Prepared according to the procedure described for example 14 from 1-(5-Chloro-4-nitro-2-thienyl)ethanone (0.1 g, 0.49 mmol) and N-methyl imidazole-2-thiol (0.056 g, 0.49 mmol). The title compound was obtained as a solid (50 mg, 36% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.48 (2H, s) 7.64 (2H, dd) 7.28 (2H, dd), 3.42 (3H, s), 2.52 (3H, s). MS m/z: 283.9 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c0d16a3f21b44c82be91a8474233e025
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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