2,3,5,6-Tetrafluorobenzenethiol → HCID 46932325, compound

HRID 1192066Notes

Reaction equation

HRID 1192066 reaction equation
Cl[C:2]1[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[F:13][C:14]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:15]=1[SH:23]>>[N+:10]([C:3]1[CH:4]=[C:5]([C:7](=[O:9])[CH3:8])[S:6][C:2]=1[S:23][C:15]1[C:14]([F:13])=[C:19]([F:20])[CH:18]=[C:17]([F:21])[C:16]=1[F:22])([O-:12])=[O:11]

Participants

3

Reactant 2

HCID 698592,3,5,6-TetrafluorobenzenethiolHCID 5211051-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-one

Product 1

HCID 46932325HCID 46932325, compoundYield 18%

Procedure

Prepared by a similar procedure to that described for example 18 from the 1-(5-chloro-4-nitro-2-thienyl)ethanone (200 mg, 0.98 mmol) and 2,3,5,6-tetrafluorobenzenethiol (178 mg, 0.98 mmol) to afford the title product as a solid (60 mg, 18% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.54 (1H, s), 8.41 (1H, m). MS m/z: 349.75 [M+H]+.

Workup

  1. customPrepared by a similar procedure to

Sources & evidence

ORD record
ord-35bfc714cf11456d89b8ec343a6538b8
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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