2-Methoxyethylamine → HCID 46932518, compound

HRID 1192086Notes

Reaction equation

HRID 1192086 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][O:22][CH2:23][CH2:24][NH2:25]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:25][CH2:24][CH2:23][O:22][CH3:21])=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 46932518HCID 46932518, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (100 mg, 0.28 mmol) and 2-Methoxy ethylamine (25 mg, 0.32 mmol). The title compound was obtained as a solid (52 mg, 46% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.99 (2H, m), 8.95 (1H, m), 8.46 (1H, m), 3.39 (2H, m), 3.35 (2H, m), 3.24 (3H, s). MS m/z: 405.99, 407.99 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bfc17820139945b3850455a45fcfdc68
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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