2-Phenoxyethanamine → HCID 46932519, compound

HRID 1192087Notes

Reaction equation

HRID 1192087 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[O:21]([CH2:28][CH2:29][NH2:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH2:29][CH2:28][O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 156512-PhenoxyethanamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 46932519HCID 46932519, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (100 mg, 0.28 mmol) and 2-Phenoxy ethylamine (45 mg, 0.32 mmol). The title compound was obtained as a solid (32 mg, 24% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.11 (1H, m), 8.99 (2H, m), 8.47 (1H, s), 7.27 (2H, m), 6.93 (3H, m), 4.04 (2H, m), 3.56 (2H, m). MS m/z: 468.03, 470.03 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ac16f7037a3c43b89e6760f77a94c1b1
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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