1-(2-Hydroxyethyl)piperazine → HCID 46932610, compound

HRID 1192093Notes

Reaction equation

HRID 1192093 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[N:21]1([CH2:27][CH2:28][OH:29])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([N:24]2[CH2:25][CH2:26][N:21]([CH2:27][CH2:28][OH:29])[CH2:22][CH2:23]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 46932610HCID 46932610, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 2-piperazin-1-ylethanol (26.0 mg, 0.2 mmol). The title compound was obtained as a solid (23.0 mg, 50% yield). 1H NMR (300 MHz, d6-DMSO) δ: 8.75 (2H, s), 7.80 (1H, s), 4.87 (4H, m), 4.23 (4H, m), 4.04 (2H, m), 3.22 (2H, m). MS m/z: 462.90, 464.90 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f695d1dc6f424482b02a2490bda31295
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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