4,4-Dimethylpiperidine → HCID 60207322, compound

HRID 1192107Notes

Reaction equation

HRID 1192107 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][C:22]1([CH3:28])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([N:25]2[CH2:26][CH2:27][C:22]([CH3:28])([CH3:21])[CH2:23][CH2:24]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 1381004,4-DimethylpiperidineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207322HCID 60207322, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (200 mg, 0.56 mmol) and 4,4-dimethyl piperidine (83 mg, 0.65 mmol). The title compound was obtained as a solid (34 mg, 14% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.97 (2H, s), 7.90 (1H, s), 3.57 (4H, m), 1.33 (4H, m), 0.95 (6H, s). MS m/z: 446.21, 448.23 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9d6be1cba00c4ce6bf0d051078e8ece6
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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