3-Methoxybenzylamine → HCID 67495143, compound

HRID 1192120Notes

Reaction equation

HRID 1192120 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][O:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26][NH2:27]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:27][CH2:26][C:25]2[CH:28]=[CH:29][CH:30]=[C:23]([O:22][CH3:21])[CH:24]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 211563-MethoxybenzylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 67495143HCID 67495143, compound

Procedure

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (200 mg, 0.57 mmol) and 3-methoxy benzylamine (104 mg, 0.68 mmol). The title compound was obtained as a yellow solid (35 mg, 14% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.37 (1H, m), 8.98 (2H, m), 8.47 (1H, s), 7.23 (1H, m), 6.83 (3H, m) 4.37 (2H, m), 3.72 (3H, s). MS m/z: 468.26, 470.28 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-316f8fd169914859b450629bdf222dbd
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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