Tert-Butylamine → HCID 60207382, compound

HRID 1192166Notes

Reaction equation

HRID 1192166 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[C:21]([NH2:25])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([NH:25][C:14]([C:12]1[S:13][C:9]([S:8][C:7]2[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=2[Cl:20])=[C:10]([N+:17]([O-:19])=[O:18])[CH:11]=1)=[O:15])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 602073375-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chloride

Product 1

HCID 60207382HCID 60207382, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and t-butylamine (36 mg, 0.39 mmol). The title compound was obtained as a solid (25 mg, 15% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, s), 8.57 (1H, s), 8.23 (1H, s), 1.31 (9H, s). MS m/z: 404.09, 406.07 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d87f1e997f1447e78edd5fa17a0cda28
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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