Methyl 4-(aminomethyl)benzoate hydrochloride → HCID 60207391, compound

HRID 1192175Notes

Reaction equation

HRID 1192175 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].Cl.[NH2:22][CH2:23][C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:32][CH:33]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 2729253Methyl 4-(aminomethyl)benzoate hydrochlorideHCID 602073375-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chloride

Product 1

HCID 60207391HCID 60207391, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and methyl 4-(aminomethyl)benzoate hydrogen chloride (81 mg, 0.39 mmol). The title compound was obtained as a solid (70 mg, 35% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.46 (1H, m), 8.98 (2H, s), 8.48 (1H, s), 7.91 (2H, m), 7.43 (2H, m), 4.49 (2H, m), 3.84 (3H, s). MS m/z: 496.31, 498.15 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b313e45f129a4f2583bdeb6d73c99bf1
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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