4-Hydroxybenzylamine → HCID 60207393, compound

HRID 1192177Notes

Reaction equation

HRID 1192177 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[OH:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:27][CH2:26][C:25]2[CH:28]=[CH:29][C:22]([OH:21])=[CH:23][CH:24]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 974724-HydroxybenzylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207393HCID 60207393, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 4-hydroxylbenzylamine (14.5 mg, 0.12 mmol). The title compound was obtained as a solid (23.1 mg, 51% yield). MS m/z: 455.96, 457.96 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f2def09da5b74874b5a9d6d0a3939f94
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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