1-[2-(Dimethylamino)ethyl]-3-methyl-1H-pyrazol-5-amine → HCID 60207406, compound

HRID 1192191Notes

Reaction equation

HRID 1192191 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][N:22]([CH3:32])[CH2:23][CH2:24][N:25]1[C:29]([NH2:30])=[CH:28][C:27]([CH3:31])=[N:26]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][C:29]2[N:25]([CH2:24][CH2:23][N:22]([CH3:32])[CH3:21])[N:26]=[C:27]([CH3:31])[CH:28]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 27585011-[2-(Dimethylamino)ethyl]-3-methyl-1H-pyrazol-5-amineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207406HCID 60207406, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 1-(2-(dimethylamino)ethyl)-3-methyl-1H-pyrazol-5-amine (17.0 mg, 0.10 mmol). The title compound was obtained as a solid (20.8 mg, 23% yield). MS m/z: 501.02, 503.02 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-07ccb6ceaa6f40f8a5093c1a4c01e6a4
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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