(3-Aminopropoxy)(tert-butyl)dimethylsilane → HCID 60207448, compound

HRID 1192225Notes

Reaction equation

HRID 1192225 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[Si:21]([O:28][CH2:29][CH2:30][CH2:31][NH2:32])([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22]>>[Si:21]([O:28][CH2:29][CH2:30][CH2:31][NH:32][C:14]([C:12]1[S:13][C:9]([S:8][C:7]2[C:6]([Cl:20])=[CH:5][N:4]=[CH:3][C:2]=2[Cl:1])=[C:10]([N+:17]([O-:19])=[O:18])[CH:11]=1)=[O:16])([C:24]([CH3:26])([CH3:27])[CH3:25])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 11074190(3-Aminopropoxy)(tert-butyl)dimethylsilaneHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207448HCID 60207448, compound

Procedure

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (1.5 g, 4.3 mmol) and 3-(tert-butyl(dimethyl)silyl)oxypropan-1-amine (0.98 g, 5.12 mmol). The title compound was obtained as a yellow solid (1.1 g, 49% yield).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d0dc248671554950917bf23198554af1
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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