2,6-Dichlorophenol → HCID 60207492, compound

HRID 1192269Notes

Reaction equation

HRID 1192269 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[OH:9].Cl[C:11]1[S:15][C:14]([C:16]([O:18][CH3:19])=[O:17])=[CH:13][C:12]=1[N+:20]([O-:22])=[O:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[O:9][C:11]1[S:15][C:14]([C:16]([O:18][CH3:19])=[O:17])=[CH:13][C:12]=1[N+:20]([O-:22])=[O:21]

Participants

3

Reactant 2

HCID 68992,6-DichlorophenolHCID 13205564Methyl 5-chloro-4-nitrothiophene-2-carboxylate

Product 1

HCID 60207492HCID 60207492, compound

Procedure

Prepared according to the procedure described for step A of example 18 from 2,6-dichloro-phenol (368 mg, 2.26 mmol) and methyl 5-chloro-4-nitro-thiophene-2-carboxylate (500 mg, 2.26 mmol). The title compound was obtained as a white solid (500 mg, 65% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.12 (1H, m), 7.80 (2H, m), 7.58 (1H, m), 3.80 (3H, s). MS m/z: 365.07, 367.00 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f2db0b0955994ed1a66311399a5b186a
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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