5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid → HCID 178439393, compound

HRID 1192271Notes

Reaction equation

HRID 1192271 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH:21]([C:24]1[CH:28]=[C:27]([NH2:29])[NH:26][N:25]=1)([CH3:23])[CH3:22]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:29][C:27]2[NH:26][N:25]=[C:24]([CH:21]([CH3:23])[CH3:22])[CH:28]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acidHCID 178439404HCID 178439404, compound

Product 1

HCID 178439393HCID 178439393, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 3-isopropyl-1H-pyrazol-5-amine (12.5 mg, 0.1 mmol). The title compound was obtained as a solid (7.1 mg, 16% yield). MS m/z: 458.00, 460.00 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fc42d1df16c641cebeed6b282f1c3244
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

Loading…