N-(tert-butoxycarbonyl)glycine → HCID 59395942, compound

HRID 1192285Notes

Reaction equation

HRID 1192285 reaction equation
[NH2:1][C@H:2]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][N:12]=2)[CH2:7][CH2:6]1)=[O:4].C([NH:35][CH2:36][C:37](O)=[O:38])(OC(C)(C)C)=O>>[NH2:35][CH2:36][C:37]([NH:1][C@H:2]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][N:12]=2)[CH2:7][CH2:6]1)=[O:4])=[O:38]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 52947490HCID 52947490, compound

Product 1

HCID 59395942HCID 59395942, compound

Procedure

(2R)-2-Amino-3-phenyl-1-(4-quinazolin-4-yl-piperazin-1-yl)-propan-1-one (free-base) was acylated with Boc-glycine and deprotected according to Step 2 of Example 1 to furnish (2R)-2-(2-Aminoacetamido)-3-phenyl-1-(4-quinazolin-4-yl-piperazin-1-yl)-propan-1-one. Rt 2.23. MS (ESI+) [M+H]+ 419.

Sources & evidence

ORD record
ord-8f5fb15821284b32a66768ea6176ccfb
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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