Hydrochloric Acid → HCID 67539834, compound

HRID 1192310Notes

Reaction equation

HRID 1192310 reaction equation
C(OC(=O)[NH:7][CH:8]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)[C:9](=[O:28])[N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[S:24][C:23]([C:25]#[C:26][CH3:27])=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][CH2:11]1)(C)(C)C.[ClH:38]>C(Cl)Cl.O1CCOCC1>[ClH:36].[ClH:38].[NH2:7][CH:8]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)[C:9]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[S:24][C:23]([C:25]#[C:26][CH3:27])=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][CH2:11]1)=[O:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67540509HCID 67540509, compound

Product 1

HCID 67539834HCID 67539834, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of {1-(4-chlorobenzyl)-2-oxo-2-[4-(6-prop-1-ynyl-thieno[3,2-d]pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester in DCM (4 mL) was added HCl in Dioxane (4M, 1 mL). The mixture was stirred for 4 hours. The solvent was removed to afford the product 2-Amino-3-(4-chlorophenyl)-1-[4-(6-prop-1-ynyl-thieno[3,2-d]pyrimidin-4-yl)-piperazin-1-yl]-propan-1-one dihydrochloride quantitatively. MS (ESI+) [M+H]+ 440.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-664f6c02fe9f4c8fbd91a31c911bd5ea
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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