Hydrochloric Acid → HCID 67538855, compound

HRID 1192352Notes

Reaction equation

HRID 1192352 reaction equation
[ClH:1].[C:2]1([S:8]([N:11]2[C:15]3=[N:16][CH:17]=[N:18][C:19]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)=[C:14]3[C:13]([Br:26])=[N:12]2)(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[ClH:1].[ClH:1].[C:2]1([S:8]([N:11]2[C:15]3=[N:16][CH:17]=[N:18][C:19]([N:20]4[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]4)=[C:14]3[C:13]([Br:26])=[N:12]2)(=[O:9])=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67538856HCID 67538856, compound

Product 1

HCID 67538855HCID 67538855, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Anhydrous HCl (4N in dioxane, 10 mL) was added to a stirred solution of 1-Benzenesulfonyl-3-bromo-4-piperazin-1-yl-1H-pyrazolo[3,4-d]pyrimidine (210 mg, 0.40 mmol) in MeOH (20 mL) and stirred at room temperature overnight. The suspension was concentrated in vacuo to give 1-Benzenesulfonyl-3-bromo-4-piperazin-1-yl-1H-pyrazolo[3,4-d]pyrimidine dihydrochloride (200 mg, 100%.) LCMS (APCI+) m/z 423 and 425 [M+H]+; Rt: 1.98 min.

Workup

  1. concentrationThe suspension was concentrated in vacuo

Sources & evidence

ORD record
ord-84fc83abcc014b0cacee5df6383163e1
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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