Dichloromethane → 853680-34-9

HRID 1192378Notes

Reaction equation

HRID 1192378 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(Cl)[Cl:24]>Cl.CCOCC>[ClH:24].[ClH:24].[N:11]1([C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 67538852HCID 67538852, compound

Product 1

HCID 67539435853680-34-9

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 4-imidazo[1,2-a]pyridin-3-yl-piperazine-1-carboxylic acid tert-butyl ester (950 mg, 3.14 mmol) in DCM (10 mL) and 2.0N HCl in Et2O (5 mL) was stirred for 12 hours. A precipitate formed and was filtered off to give 3-piperazin-1-yl-imidazo[1,2-a]pyridine dihydrochloride as a red solid (800 mg).

Workup

  1. customA precipitate formed
  2. filtrationwas filtered off

Sources & evidence

ORD record
ord-092465cf7d504b6c93c4f7cbc449063b
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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