Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of (7S)-4-(7-Methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (32 mg, 0.096 mmol) in DCM (2 mL) was added HCl in dioxane (4M, 2 mL). The mixture was stirred at room temperature for 3 hours. The solvent was removed to give (7S)-7-Methyl-4-piperazin-1-yl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine as HCl salt (22 mg, 99%). MS (APCI+) [M+H]+234.

Provenance & Evidence