Hydrochloric Acid → Hydrochloric Acid

HRID 1192410Notes

Reaction equation

HRID 1192410 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[CH2:23][CH2:22][C@H:21]([CH3:24])[NH:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>C(Cl)Cl.O1CCOCC1>[CH3:24][C@@H:21]1[NH:20][C:16]2[N:17]=[CH:18][N:19]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:15]=2[CH2:23][CH2:22]1.[ClH:25]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67539196HCID 67539196, compound

Product 2

HCID 313Hydrochloric AcidYield 99%HCID 67540019HCID 67540019, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (7S)-4-(7-Methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (32 mg, 0.096 mmol) in DCM (2 mL) was added HCl in dioxane (4M, 2 mL). The mixture was stirred at room temperature for 3 hours. The solvent was removed to give (7S)-7-Methyl-4-piperazin-1-yl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine as HCl salt (22 mg, 99%). MS (APCI+) [M+H]+234.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-e6a2284c24484049affc673c08b15ef3
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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