Hydrochloric Acid → Hydrochloric Acid

HRID 1192422Notes

Reaction equation

HRID 1192422 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[CH2:23][CH2:22][CH2:21][NH:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>C(Cl)Cl.O1CCOCC1>[N:11]1([C:14]2[C:15]3[CH2:23][CH2:22][CH2:21][NH:20][C:16]=3[N:17]=[CH:18][N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1.[ClH:24]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67538462HCID 67538462, compound

Product 2

HCID 313Hydrochloric AcidYield 99%HCID 67538983HCID 67538983, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-(5,6,7,8-Tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (0.88 g, 2.75 mmol) in DCM (10 mL) was added HCl in dioxane (4M, 5 mL). The mixture was stirred at RT for 4 hours. The solvent was removed to give 4-Piperazin-1-yl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine as HCl salt (0.80 g, 99%). MS (APCI+) [M+H]+220.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-1aa1831cd42a44eda578005a3328d0c3
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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