HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(5-Methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 67539665 | — |
| Product | Trifluoroacetic acid | HCID 6422 | 99% |
| Product | 5-methyl-4-piperazin-1-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine | HCID 67539172 | — |
Reaction Steps
A solution of 4-(5-Methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (0.30 g, 0.68 mmol) in TFA (20 mL) was heated to 65° C. overnight. After cooling, the excess TFA was evaporated under vacuum to give 5-Methyl-4-piperazin-1-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine as TFA salt (0.15 g, 99%). MS (APCI+) [M+H]+220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680114B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-1518dc3b7f6a4249bb05a0cdec3bffdb |
| Source note | uspto-grants-2014_03 |