1,4-Dioxane hydrochloride → HCID 67539284, compound

HRID 1192445Notes

Reaction equation

HRID 1192445 reaction equation
C(OC(=O)[NH:7][CH:8]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:9](=[O:26])[N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[CH:25]=[CH:24][CH:23]=[N:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][CH2:11]1)(C)(C)C.[ClH:35].O1CCOCC1>C(Cl)Cl>[ClH:35].[ClH:35].[ClH:35].[NH2:7][C@H:8]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:9]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[CH:25]=[CH:24][CH:23]=[N:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][CH2:11]1)=[O:26]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67537431HCID 67537431, compound

Product 1

HCID 67539284HCID 67539284, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-benzyl-2-oxo-2-(4-pyrido[2,3-d]pyrimidin-4-yl-piperazin-yl)-ethyl-carbamic acid tert-butyl ester (0.046 mg) was dissolved in DCM (5 mL) and HCl/dioxane (0.5 mL) was added. The suspension was stirred at room temperature for 3 hours, after which it was concentrated to give (2R)-2-amino-3-phenyl-1-(4-pyrido[2,3-d]pyrimidin-4-yl-piperazin-1-yl)-propan-1-one trihydrochloride (0.031 g, 86%). Rt 1.55 min. MS (ESI+) [M+H]+363.

Workup

  1. concentrationafter which it was concentrated

Sources & evidence

ORD record
ord-b2822cbdbd51498ebe65b6861c52d89e
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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