1,4-Dioxane hydrochloride → HCID 67539284, compound

Participants

Reaction Steps

[1-benzyl-2-oxo-2-(4-pyrido[2,3-d]pyrimidin-4-yl-piperazin-yl)-ethyl-carbamic acid tert-butyl ester (0.046 mg) was dissolved in DCM (5 mL) and HCl/dioxane (0.5 mL) was added. The suspension was stirred at room temperature for 3 hours, after which it was concentrated to give (2R)-2-amino-3-phenyl-1-(4-pyrido[2,3-d]pyrimidin-4-yl-piperazin-1-yl)-propan-1-one trihydrochloride (0.031 g, 86%). Rt 1.55 min. MS (ESI+) [M+H]+363.

Provenance & Evidence