反应详情

温度

-5 °C

A solution of methyl 6-amino-4-chloro-3′-fluoro-5-[(trimethylsilyl)ethynyl]biphenyl-2-carboxylate (3.2 g, 8.4 mmol) in tetrahydrofuran (8.1 mL), acetonitrile (8.1 mL), and water (9.3 mL) was cooled to −5° C. and treated with 12 M of hydrogen chloride in water (5.6 mL, 68 mmol) dropwise followed by a solution of sodium nitrite (1.2 g, 17 mmol) in water (6.3 mL)/acetonitrile (2.1 mL) and stirred at −5° C. for 30 minutes. This mixture was added to a solution of diethylamine (8.7 mL, 84 mmol) and potassium carbonate (7.0 g, 51 mmol) in water (76 mL)/acetonitrile (25 mL) that was cooled at 0° C. The reaction mixture was stirred at 0° C. for 30 minutes and warmed to 20° C. The reaction mixture was diluted with saturated sodium bicarbonate (100 mL) and extracted with ethyl acetate (200 mL). The organic layer was separated, washed with brine, dried with sodium sulfate, filtered, and concentrated to a crude oil. Purification by flash column chromatography using dichloromethane in hexanes (0%-50%) gave the desired product (3.3 g, 86%). LCMS for C23H28ClFN3O2Si (M+H)+: m/z=460.2; Found: 459.8.

1. temperaturewas cooled at 0° C
2. stirringThe reaction mixture was stirred at 0° C. for 30 minutes
3. temperaturewarmed to 20° C
4. extractionextracted with ethyl acetate (200 mL)
5. customThe organic layer was separated
6. washwashed with brine
7. dry with materialdried with sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated to a crude oil
10. customPurification by flash column chromatography