Ethanol → HCID 58368523, compound

HRID 1192525Notes

Reaction equation

HRID 1192525 reaction equation
C(O)C.[F:4][C:5]1[CH:6]=[C:7]([C:11]2[C:16]([N+:17]([O-])=O)=[C:15]([C:20]#[C:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C:14]([F:26])=[CH:13][C:12]=2[C:27](=[O:29])[CH3:28])[CH:8]=[CH:9][CH:10]=1>CO>[NH2:17][C:16]1[C:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([F:4])[CH:6]=2)=[C:12]([C:27](=[O:29])[CH3:28])[CH:13]=[C:14]([F:26])[C:15]=1[C:20]#[C:21][Si:22]([CH3:24])([CH3:23])[CH3:25]

Participants

4

Reactant 2

HCID 702EthanolHCID 58368569HCID 58368569, compound

Product 1

HCID 58368523HCID 58368523, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The desired compound was prepared according to the procedure of Example 16, step F, using ethanol (instead of methanol) and 1-{3′,4-difluoro-6-nitro-5-[(trimethylsilyl)ethynyl]biphenyl-2-yl}ethanone as the starting material in 90% yield. LCMS for C19H20F2NOSi (M+H)+: m/z=344.1; Found: 343.9.

Sources & evidence

ORD record
ord-6c18be7752e34cc396d61dfc088426eb
Source dataset
uspto-grants-2014_03
Patent number
US08680108B2

Reaction notes

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