(3,5-Difluorophenyl)boronic acid → HCID 58368637, compound

HRID 1192528Notes

Reaction equation

HRID 1192528 reaction equation
[Cl:1][C:2]1[C:3]([C:23]#[C:24][Si:25]([CH3:28])([CH3:27])[CH3:26])=[C:4]([N+:20]([O-:22])=[O:21])[C:5](OS(C(F)(F)F)(=O)=O)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[C:34]([F:36])[CH:35]=1>>[Cl:1][C:2]1[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:5]([C:32]2[CH:31]=[C:30]([F:29])[CH:35]=[C:34]([F:36])[CH:33]=2)=[C:4]([N+:20]([O-:22])=[O:21])[C:3]=1[C:23]#[C:24][Si:25]([CH3:26])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 58368634HCID 58368634, compound

Product 1

HCID 58368637HCID 58368637, compoundYield 82%

Procedure

The desired compound was prepared according to the procedure of Example 16, step E, using methyl 5-chloro-3-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}-4-[(trimethylsilyl)ethynyl]benzoate and (3,5-difluorophenyl)boronic acid as the starting materials in 82% yield. LCMS for C19H17ClF2NO4Si (M+H)+: m/z=424.1; Found: 423.9.

Sources & evidence

ORD record
ord-d85a203e2e5a4c4c99cc1a3f324f5aa1
Source dataset
uspto-grants-2014_03
Patent number
US08680108B2

Reaction notes

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