反应详情

温度

110 °C

A mixture of methyl 5-chloro-2-hydroxy-4-iodo-3-nitrobenzoate (5.00 g, 14.0 mmol) and copper cyanide (1.9 g, 21 mmol) in N,N-dimethylformamide (25 mL) was heated at 110° C. for 2 hours. After cooling to room temperature, the mixture was quenched with 1 N HCl and extracted with ethyl acetate. The combined organic layers were washed with water, brine, dried over magnesium sulfate and then evaporated to dryness under reduced pressure. The residue was used directly in the next step (3.6 g, 100%).

1. temperatureAfter cooling to room temperature
2. customthe mixture was quenched with 1 N HCl
3. extractionextracted with ethyl acetate
4. washThe combined organic layers were washed with water, brine
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness under reduced pressure