反应详情

A mixture of 1-(4-chloro-3′-fluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone (4.43 g, 14.4 mmol) in 80 mL of methanol was hydrogenated in the presence of 443 mg of 5% Pt/C, under ballon pressure of hydrogen, overnight. After filtered off catalyst, the filtrate was concentrated under reduced pressure to give the desired product (4.00 g, 100%). LCMS calculated for C15H14ClFNO (M+H)+: m/z=278.1; Found: 278.1.

1. filtrationAfter filtered off catalyst
2. concentrationthe filtrate was concentrated under reduced pressure