HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Chloro-3',5'-difluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone → 1-(6-Amino-4-chloro-3',5'-difluoro-5-methylbiphenyl-2-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Chloro-3',5'-difluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone | HCID 86656187 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(6-Amino-4-chloro-3',5'-difluoro-5-methylbiphenyl-2-yl)ethanone | HCID 58368517 | — |
Reaction Steps
A mixture of 1-(4-chloro-3′,5′-difluoro-5-methyl-6-nitrobiphenyl-2-yl)ethanone (8.61 g 26.4 mmol) in 160 mL of methanol was hydrogenated in the presence of 0.86 of 5% Pt/C, under ballon pressure of hydrogen, overnight. After filtering off catalyst, the filtrate was concentrated under reduced pressure to give the desired product. LCMS calculated for C15H13ClF2NO (M+H)+: m/z=296.1; Found: 296.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680108B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-18fa23bdd80a41f3aebb8d154b5d0c3b |
| Source note | uspto-grants-2014_03 |