Cyclopropylamine → 1-Cyclopropylpiperazine

Participants

Reaction Conditions

Reaction Steps

A carousel tube was charged with sulfuric acid mono-[2-(2-sulfooxy-ethylamino)-ethyl]ester (1 g) and D2O (3 mL). To the resulting stirred solution was added then added cyclopropylamin (0.7 mL). The resulting mixture was observed to form a stirrable thick slurry, which was heated at 50° C. overnight. Comparison of the 1H NMR of the title compound with the 1H NMR of the dihydrochloride salt of the title compound confirmed that the title compound was prepared and present in the resulting solution.

Provenance & Evidence