Cyclopropylamine → 1-Cyclopropylpiperazine

HRID 1192768Notes

Reaction equation

HRID 1192768 reaction equation
S(O[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]OS(=O)(=O)O)(O)(=O)=O.[CH:16]1([NH2:19])[CH2:18][CH2:17]1>>[CH:16]1([N:19]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 407366HCID 407366, compound

Product 1

HCID 47420041-Cyclopropylpiperazine

Conditions

Temperature
50 °C

Procedure

A carousel tube was charged with sulfuric acid mono-[2-(2-sulfooxy-ethylamino)-ethyl]ester (1 g) and D2O (3 mL). To the resulting stirred solution was added then added cyclopropylamin (0.7 mL). The resulting mixture was observed to form a stirrable thick slurry, which was heated at 50° C. overnight. Comparison of the 1H NMR of the title compound with the 1H NMR of the dihydrochloride salt of the title compound confirmed that the title compound was prepared and present in the resulting solution.

Workup

  1. additionwas added
  2. customto form a stirrable thick slurry, which

Sources & evidence

ORD record
ord-c2ffced63384437a83a44fe276e14b45
Source dataset
uspto-grants-2014_03
Patent number
US08680273B2

Reaction notes

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