4-Cyanobenzaldehyde → 4-Cyanobenzaldehyde oxime

HRID 1192786노트

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HRID 1192786 반응식
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)=O.Cl.[NH2:12][OH:13].C([O-])(=O)C.[Na+]>CO.CCOCC>[OH:13][N:12]=[CH:1][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 660424-CyanobenzaldehydeHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 52147424-Cyanobenzaldehyde oxime수율 89%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

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온도
70 °C

실험 절차

The compound was prepared according to Biasotti et al. Bioorg. Med. Chem. 2003, 11, 2247. A suspension of 4-formylbenzonitrile (500 mg, 3.81 mmol, 1.00 eq), hydroxylamine hydrochloride (290 mg, 4.19 mmol, 1.10 eq), and sodium acetate (1.56 g, 19.05 mmol, 5.00 eq) in MeOH (50 mL) was heated at 70° C. for 4 h before concentration to dryness. The residue was then slurried in Et2O, filtered, and concentrated to afford the desired intermediate (496 mg, 3.39 mmol, 89%).

후처리

  1. customThe compound was prepared
  2. filtrationfiltered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c574adc4c8694e03bddc1407c544eb3f
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680269B2

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