2,6-Dichloropyrazine → HCID 57824459, compound

HRID 1192810Notes

Reaction equation

HRID 1192810 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[F:9][C:10]([F:22])([F:21])[O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>[Pd]>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([C:15]2[CH:14]=[CH:13][C:12]([O:11][C:10]([F:9])([F:21])[F:22])=[CH:17][CH:16]=2)[N:3]=1

Participants

4

Reactant 2

HCID 785042,6-DichloropyrazineHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 57824459HCID 57824459, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The compound was prepared by palladium-catalyzed arylation of 2,6-dichloropyrazine and 4-trifluoromethoxyphenyl boronic acid: mp 58-60° C.; 1H NMR (400 MHz, CDCl3) δ 8.94 (s, 1H), 8.57 (s, 1H), 8.10 (d, J=9.0 Hz, 2H), 7.37 (d, J=8.4 Hz, 2H); EIMS m/z 274 (M+).

Sources & evidence

ORD record
ord-55afd828cbac468bac187357c91f0145
Source dataset
uspto-grants-2014_03
Patent number
US08680269B2

Reaction notes

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