Methyl iodide → HCID 66864588, compound

HRID 1192907Notes

Reaction equation

HRID 1192907 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][C:4]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH2:3]1.[CH3:28][I:29]>C(Cl)Cl>[I-:29].[CH2:26]([O:25][C:23](=[O:24])[CH2:22][C:4]1([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH2:5][CH2:6][N+:2]([CH3:28])([CH3:1])[CH2:3]1)[CH3:27]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 66865144HCID 66865144, compound

Product 1

HCID 66864588HCID 66864588, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ethyl 2-(1-methyl-3-(4-pentylphenylsulfonamido)pyrrolidin-3-yl)acetate (25 mg, 0.063 mmol) in methylene chloride (1 mL) was added methyl iodide (100 μL). The solution was stirred overnight and concentrated to give the title compound as a white solid (33 mg, quantitative). ESI 411.3 [M]+, calcd for [C21H35N2O4S]+ 411.23.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-561e003c6d74447eb9d6c1002992b0a7
Source dataset
uspto-grants-2014_03
Patent number
US08680282B2

Reaction notes

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