Methyl iodide → HCID 66866236, compound

HRID 1192910Notes

Reaction equation

[CH2:1]([C:11]1[CH:31]=[CH:30][C:14]([C:15]([NH:17][C:18]2([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19]2)=[O:16])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH3:32][I:33]>>[I-:33].[CH2:1]([C:11]1[CH:31]=[CH:30][C:14]([C:15]([NH:17][C:18]2([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:22][CH2:21][N+:20]([CH3:32])([CH3:23])[CH2:19]2)=[O:16])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 66865240HCID 66865240, compound

Product 1

HCID 66866236HCID 66866236, compound

Procedure

According to the method described in example 2a, ethyl 2-(3-(4-decylbenzamido)-1-methylpyrrolidin-3-yl)acetate (35 mg, 0.08 mmol) was reacted with methyl iodide to give the title compound as a white solid (46 mg, quantitive). MS ESI 445.3 [M]+, calcd for [C27H45N2O3+] 445.34.

Sources & evidence

ORD record: ord-45aeb8397b0a43018e860f73e3b04600
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680282B2

Reaction notes

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