反应详情

4-Bromomethyl-1-methyl-5-(oxetan-3-yloxy)-3-trifluoromethyl-1H-pyrazole (10.1 g, 32.2 mmol) and thiourea (2.7 g, 35.5 mmol) were stirred in ethanol (100 ml) at room temperature until the solids were dissolved. 3-Methanesulfonyl-5,5-dimethyl-4,5-dihydroisoxazole (6.28 g, 35.5 mmol) and potassium carbonate (4.91 g, 35.5 mmol) were added and the mixture was heated under reflux for 2 hours. The mixture was concentrated and purified by chromatography (eluent: ethyl acetate/hexane) to give the product as a white solid (4 g, 34% yield over two steps).

1. dissolutionwere dissolved
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hours
4. concentrationThe mixture was concentrated
5. custompurified by chromatography (eluent: ethyl acetate/hexane)