反应详情

温度

120 °C

A solution of 2-(4-hydroxy-2,6-dimethylphenyl)-3-methoxy-5-(tetrahydropyran-4-ylmethyl)cyclopent-2-enone (0.375 g, 0.0014 mol) in a mixture of 2M hydrochloric acid (3 ml) and acetone (5 ml) is heated at 120° C. for 30 minutes under microwave irradiation. The reaction mixture is concentrated in vacuo then azeotroped with toluene to afford 2-(4-hydroxy-2,6-dimethylphenyl)-4-(tetrahydropyran-4-ylmethyl)cyclopentane-1,3-dione as a cream solid.

1. concentrationThe reaction mixture is concentrated in vacuo
2. customthen azeotroped with toluene