5-Fluoro-2-iodobenzoic acid → 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

HRID 1193066Notes

Reaction equation

HRID 1193066 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].FC1C=CC(I)=C(C=1)C(O)=O>>[N:12]1[N:11]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:10][C:6]=2[C:7]([OH:9])=[O:8])[N:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 213135922-(2H-1,2,3-Triazol-2-yl)benzoic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 13, substituting 2-iodo-benzoic acid for 5-fluoro-2-iodo-benzoic acid. 1H NMR (400 MHz, CD3OD): 7.91 (s, 2H), 7.85-7.82 (m, 1H), 7.75 (dd, J=8.1, 1.0 Hz, 1H), 7.69 (td, J=7.7, 1.5 Hz, 1H), 7.60-7.55 (m, 1H).

Sources & evidence

ORD record
ord-68dce9a6e2c3497f934df72ee00a9e7f
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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