反应详情

To (1R,6S)-tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate (166 mg, 0.8 mmol) and DIPEA (404 μL, 2.3 mmol) in ACN (3.4 mL) was added 2-chloro-4-(trifluoromethyl)pyrimidine (110 μL, 0.9 mmol). The reaction mixture was heated at reflux for 2 h, cooled to rt, diluted with water and extracted with CH2Cl2 (2×). The combined organics were dried (Na2SO4) and concentrated to give 185 mg (66%) of the title compound as a clear oil which was used without further purification. MS (ESI) mass calcd. For C16H21F3N4O2, 358.40; m/z found 359.1 [M+H]+

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 2 h
3. extractionextracted with CH2Cl2 (2×)
4. dry with materialThe combined organics were dried (Na2SO4)
5. concentrationconcentrated